Research Program long ref
نویسنده
چکیده
General hypothesis Microglia in the injured brain comprise a family of cells with different phenotypes and origin; some which are beneficial for the injured CNS and others that are more of a destructive nature. The different phases of inflammation need to be controlled, from the acute, subacute phase of the injury in the brain. The basic questions we ask are: How can destructive microglia/neuroinflammation be regulated into a protective mode? Can modulation of neuroinflammation mitigate post-stroke depression/anxiety. What instructs microglia to acquire a particular phenotype and is the phenotype of resident microglia different from the phenotype of blood-derived microglia?
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